Introduction : pulmonary disease is a public health problem. It is disabling, responsible for a profound deterioration in the state of health of the COPD patient. Methods : This is a prospective observational study of a cohort of patients with COPD diagnosed and evaluated in four stages according to the GOLD criteria. The quality of life was apprehended using the CAT questionnaire translated into dialectal Arabic and completed by the patient in a stable state. The aim of this work is to evaluate the quality of life of COPD patients and its correlation with the severity of the disease, the frequency of exacerbations and the presence of co morbidities. Results : These are 135 COPD patients, divided into 5% stage I, 64.4% II, 26.7% III and 3.7% stage IV. The CAT score varies from 7 to 37 with an average of 16.42 ± 6. In univariate analysis, the CAT score is closely correlated with age (DS: p : 0.000), the stage of dyspnea evaluated by the Mmrc scale (p:000), FEV % (P:001), BODE index (p:0.000) and exacerbation frequency (p:0.000). dyspnoea, the BODE index and the frequency of exacerbations. Conclusion : The quality of life of patients with COPD is impaired even at an early stage of the disease. A deterioration in the quality of life is correlated with dyspnoea and the frequency of exacerbations and with the BODE index.